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1

Antiviral activities of coffee extracts in vitro

Hirotoshi Utsunomiya, Masao Ichinose, Misao Uozaki, Kazuko Tsujimoto, Hisashi Yamasaki, A. Hajime Koyama

Journal:

Food and Chemical Toxicology

Year:

2008

Language:

english

File:

PDF, 131 KB

english, 2008

2

A novel molecular mechanism for anticancer drug-induced ovarian failure: Irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apoptosis

Utsunomiya, Tomoko, Tanaka, Tetsuji, Utsunomiya, Hirotoshi, Umesaki, Naohiko

Journal:

International Journal of Oncology

Year:

2008

Language:

english

File:

PDF, 385 KB

english, 2008

3

Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver

Junichi Shoda, Tetsuo Miura, Hirotoshi Utsunomiya, Koji Oda, Masahiro Yamamoto, Masahito Kano, Tadashi Ikegami, Naomi Tanaka, Hidetaka Akita, Kousei Ito, Hiroshi Suzuki, Yuichi Sugiyama

Journal:

Year:

2004

Language:

english

File:

PDF, 423 KB

english, 2004

4

Risk of gastric cancer in asymptomatic, middle-aged Japanese subjects based on serum pepsinogen and Helicobacter pylori antibody levels

Kimihiko Yanaoka, Masashi Oka, Noriko Yoshimura, Chizu Mukoubayashi, Shotaro Enomoto, Mikitaka Iguchi, Hirohito Magari, Hirotoshi Utsunomiya, Hideyuki Tamai, Kenji Arii, Nobutake Yamamichi, Mitsuhiro

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 224 KB

english, 2008

5

Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels

Kimihiko Yanaoka, Masashi Oka, Hiroshi Ohata, Noriko Yoshimura, Hisanobu Deguchi, Chizu Mukoubayashi, Shotaro Enomoto, Izumi Inoue, Mikitaka Iguchi, Takao Maekita, Kazuki Ueda, Hirotoshi Utsunomiya, H

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 177 KB

english, 2009

6

Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion

Kimihiko Yanaoka, Masashi Oka, Noriko Yoshimura, Hisanobu Deguchi, Chizu Mukoubayashi, Shotaro Enomoto, Takao Maekita, Izumi Inoue, Kazuki Ueda, Hirotoshi Utsunomiya, Mikitaka Iguchi, Hideyuki Tamai,

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 144 KB

english, 2010

7

Co-operative thermal inactivation of herpes simplex virus and influenza virus by arginine and NaCl

Hirotoshi Utsunomiya, Masao Ichinose, Kazuko Tsujimoto, Yukiko Katsuyama, Hisashi Yamasaki, A. Hajime Koyama, Daisuke Ejima, Tsutomu Arakawa

Journal:

International Journal of Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 293 KB

english, 2009

8

Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin–Johnson syndrome

Junichi Shoda, Hideo Suzuki, Hiroshi Suzuki, Yuichi Sugiyama, Masakazu Hirouchi, Hirotoshi Utsunomiya, Koji Oda, Toru Kawamoto, Yasushi Matsuzaki, Naomi Tanaka

Journal:

Hepatology Research

Year:

2003

Language:

english

File:

PDF, 334 KB

english, 2003

9

Expression and somatic mutation on androgen receptor gene in prostate cancer

NAOKI SEGAWA, MISA NAKAMURA, LIANG SHAN, HIROTOSHI UTSUNOMIYA, YASUSHI NAKAMURA, ICHIRO MORI, YOJI KATSUOKA, KENNICHI KAKUDO

Journal:

International Journal of Urology

Year:

2002

Language:

english

File:

PDF, 444 KB

english, 2002

10

Application of biotinylated oligonucleotide probes to the detection of pituitary hormone mRNA using Northern blot analysis,in situhybridization at the light- and electron-microscope levels

Akira Matsuno, Akira Teramoto, Susumu Takekoshi, Hirotoshi Utsunomiya, Yoshitaka Ohsugi, Seigo Kishikawa, R. Yoshiyuki Osamura, Takaaki Kirino, Ricardo V. Lloyd

Journal:

Journal of Molecular Histology

Year:

1994

Language:

english

File:

PDF, 2.50 MB

english, 1994

11

Changes in the ultrastructural distribution of prolactin and growth hormone mRNAs in pituitary cells of female rats after estrogen and bromocriptine treatment, studied using in situ hybridization with biotinylated oligonucleotide probes

Akira Matsuno, Yoshitaka Ohsugi, Hirotoshi Utsunomiya, Susumu Takekoshi, Naoko Sanno, R. Yoshiyuki Osamura, Keiichi Watanabe, Akira Teramoto, Takaaki Kirino

Journal:

Histochemistry and Cell Biology

Year:

1995

Language:

english

File:

PDF, 3.17 MB

english, 1995

12

Application of biotinylated oligonucleotide probes to the detection of pituitary hormone mRNA using Northern blot analysis,in situhybridization at the light- and electron-microscope levels

Akira Matsuno, Akira Teramoto, Susumu Takekoshi, Hirotoshi Utsunomiya, Yoshitaka Ohsugi, Seigo Kishikawa, R. Yoshiyuki Osamura, Takaaki Kirino, Ricardo V. Lloyd

Journal:

Journal of Molecular Histology

Year:

1994

Language:

english

File:

PDF, 2.50 MB

english, 1994

13

Simultaneous ultrastructural identification of growth hormone and its messenger ribonucleic acid using combined immunohistochemistry and non-radioisotopicin situhybridization: A technical note

Akira Matsuno, Hirotoshi Utsunomiya, Yoshitaka Ohsugi, Susumu Takekoshi, Naoko Sanno, R. Yoshiyuki Osamura, Koichi Nagao, Akira Tamura, Tadashi Nagashima

Journal:

Journal of Molecular Histology

Year:

1996

Language:

english

File:

PDF, 1.15 MB

english, 1996

14

Thymidine phosphorylase expression correlates with tumor differentiation and bcl-2 in invasive breast cancer

Qifenq Yang, Takeo Sakurai, Liang Shan, Goro Yoshimura, Zhigang Yu, Takaomi Suzuma, Takeshi Tamaki, Teiji Umemura, Yasushi Nakamura, Misa Nakamura, Hirotoshi Utsunomiya, Ichiro Mori, Kennichi Kakudo

Journal:

Year:

2000

Language:

english

File:

PDF, 681 KB

english, 2000

15

Thymidine phosphorylase is regulated by tamoxifen in T47D breast cancer cell line

Hirotoshi Utsunomiya, Hirokazu Ueshima, Mari Kawashiro, Qifeng Yang, Misa Nakamura, Yasushi Nakamura, Takeo Sakurai, Ichiro Mori, Kennichi Kakudo

Journal:

Year:

2002

Language:

english

File:

PDF, 472 KB

english, 2002

16

Clinical and histopathological analysis of proliferative potentials of recurrent and non-recurrent meningiomas

A. Matsuno, Takamitsu Fujimaki, Tomio Sasaki, Tadashi Nagashima, Takafumi Ide, Akio Asai, Reiko Matsuura, Hirotoshi Utsunomiya, Takaaki Kirino

Journal:

Acta Neuropathologica

Year:

1996

Language:

english

File:

PDF, 63 KB

english, 1996

17

A clinical overview of familial adenomatous polyposis derived from the database of the Polyposis Registry of Japan

Takeo Iwama, Kazuo Tamura, Takayuki Morita, Takashi Hirai, Hirotoshi Hasegawa, Koichi Koizumi, Kazuo Shirouzu, Kenichi Sugihara, Takehira Yamamura, Tetsuichiro Muto, Joji Utsunomiya, The Polyposis Com

Journal:

International Journal of Clinical Oncology

Year:

2004

Language:

english

File:

PDF, 633 KB

english, 2004

18

Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+on heparan sulfate glycosaminoglycan in mammary carcinomas—a novel proliferative biomarker for breast cancers with high malignancy

Masahiro Fujii, Akiko Yusa, Yukihiro Yokoyama, Toshio Kokuryo, Nobuyuki Tsunoda, Koji Oda, Masato Nagino, Tsuyoshi Ishimaru, Yoshie Shimoyama, Hirotoshi Utsunomiya, Hiroji Iwata, Yoshiko Itoh, Johbu I

Journal:

Glycoconjugate Journal

Year:

2010

Language:

english

File:

PDF, 943 KB

english, 2010

19

Somatic Mutations in the RET Protooncogene in Japanese and Chinese Sporadic Medullary Thyroid Carcinomas

Liang Shan, Misa Nakamura, Yasushi Nakamura, Hirotoshi Utsunomiya, Nanhai Shou, Xihong Jiang, Xuefeng Jing, Toyoharu Yokoi, Kennichi Kakudo

Journal:

Year:

1998

Language:

english

File:

PDF, 86 KB

english, 1998

20

Clonal Emergence in Uremic Parathyroid Hyperplasia Is Not Related to MEN1 Gene Abnormality

Liang Shan, Yasushi Nakamura, Maki Murakami, Misa Nakamura, Akihiro Naito, Katsuhiko Kawahara, Hirotoshi Utsunomiya, Ichiro Mori, Kennichi Kakudo

Journal:

Year:

1999

Language:

english

File:

PDF, 234 KB

english, 1999

21

Developmentally regulated expression of matrix metalloproteinases during fetal rat colon morphogenesis

Hidenori Kurakata, Masashi Oka, Yasuo Matsubara, Tohru Niwa, Hirotoshi Utsunomiya, Mitsuhiro Fujishiro, Kazumasa Miki, Hiroshi Fukamachi, Syunichiro Kubota, Masao Ichinose

Journal:

Development, Growth & Differentiation

Year:

2008

Language:

english

File:

PDF, 510 KB

english, 2008

22

An improved ultrastructural double-staining method for rat growth hormone and its mRNA using LR White resin: a technical note

Akira Matsuno, Yoshitaka Ohsugi, Hirotoshi Utsunomiya, Susumu Takekoshi, Shigeru Munakata, Koichi Nagao, R. Yoshiyuki Osamura, Akira Tamura, Tadashi Nagashima

Journal:

Journal of Molecular Histology

Year:

1998

Language:

english

File:

PDF, 578 KB

english, 1998

23

Expression of Bcl-2 but not Bax or p53 correlates with in vitro resistance to a series of anticancer drugs in breast carcinoma

Qi-Feng Yang, Takeo Sakurai, Goro Yoshimura, Liang Shan, Takaomi Suzuma, Takeshi Tamaki, Teiji Umemura, Yozo Kokawa, Yasushi Nakamura, Misa Nakamura, Weihua Tang, Hirotoshi Utsunomiya, Ichiro Mori, Ke

Journal:

Breast Cancer Research and Treatment

Year:

2000

Language:

english

File:

PDF, 52 KB

english, 2000

24

Gastrointestinal Stromal Tumors: Are They of Cajal Cell Origin?

Xiaojuan Wang, Ichiro Mori, Weihua Tang, Hirotoshi Utsunomiya, Misa Nakamura, Yasushi Nakamura, Genying Zhou, Kennichi Kakudo

Journal:

Experimental and Molecular Pathology

Year:

2002

Language:

english

File:

PDF, 391 KB

english, 2002

25

Immunoreactive characteristics and classification of hyperparathyroidism

Liang Shan, Arata Iwasaki, Hirotoshi Utsunomiya, Ichiro Kawano, Nariaki Matsuura, Akira Kobayashi, Kanji Kuma, Kennichi Kakudo

Journal:

Endocrine Pathology

Year:

1995

Language:

english

File:

PDF, 2.12 MB

english, 1995

26

Immunolocalization of parathyroid hormone in human parathyroid glands with special references to microwave antigen retrieval

Hirotoshi Utsunomiya, Liang Shan, Ichiro Kawano, Arata Iwasaki, Kazuo Ono, Akira Kobayashi, Kanji Kuma, Seigo Kishikawa, Kennichi Kakudo

Journal:

Endocrine Pathology

Year:

1995

Language:

english

File:

PDF, 1.02 MB

english, 1995

27

Immunohistochemical expression of Pit-1 protein in human pituitary adenomas

Kenichi Inada, Koji Oda, Hirotoshi Utsunomiya, Naoko Sanno, Johbu Itoh, R. Yoshiyuki Osamura, Jeffrey W. Voss, Michael G. Rosenfeld

Journal:

Endocrine Pathology

Year:

1993

Language:

english

File:

PDF, 438 KB

english, 1993

28

Cyclosporin A inhibits angiotensin II-induced c-Jun NH2-terminal kinase activation but not protein synthesis in vascular smooth muscle cells

Shuichi Saito, Gerald D. Frank, Evangeline D. Motley, Hirotoshi Utsunomiya, Tadashi Inagami, Satoru Eguchi

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 133 KB

english, 2002

29

Overexpression and genetic abnormality of p53 in parathyroid adenomas

Seigo Kishikawa, Liang Shan, Kikumi Ogihara, Hirotoshi Utsunomiya, Misa Nakamura, Yasushi Nakamura, Akihiro Naito, Kennichi Kakudo

Journal:

Pathology International

Year:

1999

Language:

english

File:

PDF, 126 KB

english, 1999

30

Expression of Bcl-2, but not Bax, correlates with estrogen receptor status and tumor proliferation in invasive breast carcinoma

Qifeng Yang, Takeo Sakurai, Xuefeng Jing, Hirotoshi Utsunomiya, Liang Shan, Yasushi Nakamura, Misa Nakamura, Shoji Oura, Takaomi Suzuma, Goro Yoshimura, Teiji Umemura, Yozo Kokawa, Kennichi Kakudo

Journal:

Pathology International

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

31

Prognostic significance of neuroendocrine differentiation, proliferation activity and androgen receptor expression in prostate cancer

Naoki Segawa, Ichiro Mori, Hirotoshi Utsunomiya, Misa Nakamura, Yasushi Nakamura, Liang Shan, Kennichi Kakudo, Yoji Katsuoka

Journal:

Pathology International

Year:

2001

Language:

english

File:

PDF, 1.23 MB

english, 2001

32

Gastrointestinal stromal tumors: Clinicopathological study of Chinese cases

Xiaojuan Wang, Ichiro Mori, Weihua Tang, Hirotoshi Utsunomiya, Misa Nakamura, Yasushi Nakamura, Genying Zhou, Kennichi Kakudo

Journal:

Pathology International

Year:

2001

Language:

english

File:

PDF, 837 KB

english, 2001

33

Microwave cell death: Immunohistochemical and enzyme histochemical evaluation

Takashi Ozaki, Ichiro Mori, Misa Nakamura, Hirotoshi Utsunomiya, Katsuyoshi Tabuse, Kennichi Kakudo

Journal:

Pathology International

Year:

2003

Language:

english

File:

PDF, 432 KB

english, 2003

34

Atypical Carcinoid Tumor of the Lung with Amyloid Stroma

Yoshiyuki Abe, Hirotoshi Utsunomiya, Yutaka Tsutsumi

Journal:

Pathology International

Year:

1992

Language:

english

File:

PDF, 877 KB

english, 1992

35

Bio-histochemical aspects of integrins (α2β1, α6β1) in invasive mammary carcinomas: An immunohistochemical study

Koji Oda, Hitoshi It Oh, Hirotoshi Utsunomiya, Johbu Itoh, R. Yoshiyuki Osamura, Yutaka Tokuda, Mitsuharu Kubota, Tomoo Tajima

Journal:

Pathology International

Year:

1994

Language:

english

File:

PDF, 865 KB

english, 1994

36

Microwave cell death: Molecular analysis using DNA electrophoresis, PCR amplification and TUNEL

Ichiro Mori, Takashi Ozaki, Katsuyoshi Tabuse, Hirotoshi Utsunomiya, Emiko Taniguchi, Kennichi Kakudo

Journal:

Pathology International

Year:

2009

Language:

english

File:

PDF, 366 KB

english, 2009

37

Adrenomedullin, Bcl-2 and microvessel density in normal, hyperplastic and neoplastic endometrium

Osamu Nunobiki, Misa Nakamura, Emiko Taniguchi, Hirotoshi Utsunomiya, Ichiro Mori, Yukari Tsubota, Yoshiya Mabuchi, Kennichi Kakudo

Journal:

Pathology International

Year:

2009

Language:

english

File:

PDF, 323 KB

english, 2009

38

Inhibitory effect of etodolac, a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils

Hirohito Magari, Yasuhito Shimizu, Ken-ichi Inada, Shotaro Enomoto, Tatsuji Tomeki, Kimihiko Yanaoka, Hideyuki Tamai, Kenji Arii, Hiroya Nakata, Masashi Oka, Hirotoshi Utsunomiya, Yutaka Tsutsumi, Tet

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 354 KB

english, 2005

39

Gastric acid reduction leads to an alteration in lower intestinal microflora

Takayuki Kanno, Takahiro Matsuki, Masashi Oka, Hirotoshi Utsunomiya, Kenichi Inada, Hirohito Magari, Izumi Inoue, Takao Maekita, Kazuki Ueda, Shotaro Enomoto, Mikitaka Iguchi, Kimihiko Yanaoka, Hideyu

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 274 KB

english, 2009

40

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

Kosuke Okada, Junichi Shoda, Keiko Taguchi, Jonathan M. Maher, Kaoru Ishizaki, Yoshimi Inoue, Makio Ohtsuki, Nobuharu Goto, Hirokazu Sugimoto, Hirotoshi Utsunomiya, Koji Oda, Eiji Warabi, Tetsuro Ishi

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 2.46 MB

english, 2009

41

ELASTIN INDUCED UPREGULATION OF M-CSF IN MACROPHAGE IS MEDIATED BY ELASTIN-LAMININ RECEPTOR

Ichiro Mori, Tomonori Higuchi, Misa Nakamura, Yasushi Nakamura, Hirotoshi Utsunomiya, Kennichi Kakudo

Journal:

Cardiovascular Pathology

Year:

2004

Language:

english

File:

PDF, 41 KB

english, 2004

42

Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice

Hirotoshi Utsunomiya, Misa Nakamura, Kennichi Kakudo, Tadashi Inagami, Masaaki Tamura

Journal:

Regulatory Peptides

Year:

2005

Language:

english

File:

PDF, 361 KB

english, 2005

43

Biallelic Inactivation of Retinoic Acid Receptor β2 Gene by Epigenetic Change in Breast Cancer

Qifeng Yang, Ichiro Mori, Liang Shan, Misa Nakamura, Yasushi Nakamura, Hirotoshi Utsunomiya, Goro Yoshimura, Takaomi Suzuma, Takeshi Tamaki, Teiji Umemura, Takeo Sakurai, Kennichi Kakudo

Journal:

The American Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 188 KB

english, 2001

44

Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation

Shuichi Saito, Gerald D Frank, Evangeline D Motley, Peter J Dempsey, Hirotoshi Utsunomiya, Tadashi Inagami, Satoru Eguchi

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 257 KB

english, 2002

45

Fruit-juice concentrate of Asian plum inhibits growth signals of vascular smooth muscle cells induced by angiotensin II

Hirotoshi Utsunomiya, Susumu Takekoshi, Nobuki Gato, Hisao Utatsu, Evangeline D Motley, Kunie Eguchi, Trinita G Fitzgerald, Mizuo Mifune, Gerald D Frank, Satoru Eguchi

Journal:

Year:

2002

Language:

english

File:

PDF, 260 KB

english, 2002

46

Thymidine phosphorylase expression in tumor stroma of uterine cervical carcinomas: histological features and microvessel density

Weihua Tang, Xiaojuan Wang, Hirotoshi Utsunomiya, Yasushi Nakamuta, Qifeng Yang, Qinhuei Zhang, Gengyen Zhou, Yukari Tsubota, Yoshiya Mabuchi, Li Li, Kennichi Kakudo

Journal:

Year:

2000

Language:

english

File:

PDF, 405 KB

english, 2000

47

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice

Junichi Shoda, Kosuke Okada, Yoichi Inada, Hiroshi Kusama, Hirotoshi Utsunomiya, Koji Oda, Tsuyoshi Yokoi, Katsutoshi Yoshizato, Hiroshi Suzuki

Journal:

Hepatology Research

Year:

2007

Language:

english

File:

PDF, 252 KB

english, 2007

48

The α-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice

Kosuke Okada, Toru Yanagawa, Eiji Warabi, Keiko Yamastu, Junya Uwayama, Koichi Takeda, Hirotoshi Utsunomiya, Hiroshi Yoshida, Junichi Shoda, Tetsuro Ishii

Journal:

Hepatology Research

Year:

2009

Language:

english

File:

PDF, 416 KB

english, 2009

49

Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliary obstruction due to bile duct carcinoma

Shinya Watanabe, Yukihiro Yokoyama, Koji Oda, Toshio Kokuryo, Junichi Shoda, Kosuke Okada, Hirotoshi Utsunomiya, Masato Nagino

Journal:

Hepatology Research

Year:

2009

Language:

english

File:

PDF, 268 KB

english, 2009

50

Expression patterns of β1-related α integrin subunits in murine lens during embryonic development and wound healing

Barbour, Walid, Saika, Shizuya, Miyamoto, Takeshi, Ohkawa, Kiyomi, Utsunomiya, Hirotoshi, Ohnishi, Yoshitaka

Journal:

Current Eye Research

Year:

2004

Language:

english

File:

PDF, 611 KB

english, 2004